In this episode of unPAUSED, Dr. Mary Claire Haver continues her conversation with breast oncologist Dr. Eleonora Teplinsky, author of Beyond the Pink. In part two, they shift from treatment to breast cancer risk, prevention, and early detection. They start with dense breasts, which about half of women have and which can both hide cancer on a mammogram and raise breast cancer risk. Dr. Teplinsky explains which breast density categories call for added breast cancer screening with MRI or ultrasound, along with why the radiation from a mammogram is lower than many women fear.
From there they turn to family history of breast cancer and why it is so often misunderstood. Only 5 to 10% of breast cancers are hereditary, so most women who are diagnosed have no family history at all, and skipping mammograms for that reason is a mistake. Dr. Teplinsky explains how to know your breast cancer risk through a formal risk assessment starting at age 25, and what happens when lifetime risk reaches 20% or higher, including referral to a high risk breast program. She walks through who should get genetic testing, why family history means both parents’ sides and several generations, and why a negative result does not bring a woman with a strong family history back to average risk. Other topics include blood tests and full body scans that promise early detection, and why women of color are offered genetic testing less often and receive inconclusive results more often.
For women with a BRCA mutation who have never had cancer, often called previvors, Dr. Teplinsky explains what a lifetime breast cancer risk of up to 80% means for decisions about risk reducing mastectomy and ovary removal. She shares new data showing that previvors in surgical menopause can use menopause hormone therapy without raising their breast cancer risk, and explains why a menopause plan should be in place before surgery, since menopause before 45 raises the risk of heart disease, cognitive decline, and osteoporosis.
The conversation then moves to life after cancer treatment. Dr. Teplinsky explains why anyone who has had chemotherapy should get a baseline bone density scan, how chemo brain mirrors menopause brain fog, and how radiation, chemotherapy, and early menopause can affect heart health and cholesterol. She also closes the conversation with ways listeners can tell ordinary fear of recurrence apart from fear that takes over daily life, and shares practical ways to cope with body image changes after mastectomy, including finding a support community that fits.
Guest Links:
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Dr. Eleonora Teplinsky
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Dr. Eleonora Teplinsky (Instagram)
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Dr. Eleonora Teplinsky (Substack)
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Dr. Eleonora Teplinsky (TikTok)
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Dr. Eleonora Teplinsky (Facebook)
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Dr. Eleonora Teplinsky (LinkedIn)
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Dr. Eleonora Teplinsky (YouTube)
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Dr. Eleonora Teplinsky (X)
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INTERLUDE: Cancer Stories with Dr. Teplinsky (Apple Podcasts)
- Living Beyond Breast Cancer
Books:
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“Beyond the Pink: Navigating Life, Health, and Breast Cancer,” by Dr. Eleonora Teplinsky
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“The New Perimenopause,” by Dr. Mary Claire Haver
- “The New Menopause" by Dr. Mary Claire Haver
Articles:
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Risks and Benefits of Estrogen Plus Progestin in Healthy Postmenopausal Women: Principal Results From the Women’s Health Initiative Randomized Controlled Trial (JAMA)
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Breast and Ovarian Cancer Among Individuals Undergoing BRCA1 and BRCA2 Testing (JAMA Network Open)
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New ACR Breast Cancer Screening Guidelines Call for Earlier Screening for High-Risk Women (American College of Radiology)
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ACR Appropriateness Criteria Supplemental Breast Cancer Screening Based on Breast Density: 2024 Update (American College of Radiology)
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Menopausal hormone therapy and the risk of breast cancer in women with a pathogenic variant in BRCA1 or BRCA2 (Journal of the National Cancer Institute)
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Menopausal Hormone Therapy May Not Pose Breast Cancer Risk for Women With BRCA Mutations (American Association for Cancer Research)
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Endometrial Cancer Risk in Women With Germline BRCA1 or BRCA2 Mutations: Multicenter Cohort Study (Journal of the National Cancer Institute)
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Uterine Cancer After Risk-Reducing Salpingo-oophorectomy Without Hysterectomy in Women With BRCA Mutations (JAMA Oncology)
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Genetic Testing for Inherited Cancer Risk (National Cancer Institute)
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Rates and Classification of Variants of Uncertain Significance in Hereditary Disease Genetic Testing (JAMA Network Open)
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Health Care Segregation, Physician Recommendation, and Racial Disparities in BRCA1/2 Testing Among Women With Breast Cancer (Journal of Clinical Oncology)
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Ovarian failure after adjuvant chemotherapy is associated with rapid bone loss in women with early-stage breast cancer (Journal of Clinical Oncology)
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Effect of an Aromatase Inhibitor on BMD and Bone Turnover Markers: 2-Year Results of the Anastrozole, Tamoxifen, Alone or in Combination (ATAC) Trial (18233230) (Journal of Bone and Mineral Research)
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Risk of Ischemic Heart Disease in Women after Radiotherapy for Breast Cancer (The New England Journal of Medicine)
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What is the prevalence of fear of cancer recurrence in cancer survivors and patients? A systematic review and individual participant data meta-analysis (Psycho-Oncology)
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Fear of Cancer Recurrence in an Era of Personalized Medicine (Journal of Clinical Oncology)
- The Mirror Program: Preparing Women for the Postoperative Mastectomy Mirror-Viewing Experience (Nursing Forum)
Other Resources:
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Dense Breasts: Answers to Commonly Asked Questions (National Cancer Institute)
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Genetic Testing to Learn About Breast Cancer Risk (Susan G. Komen)
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ACR Appropriateness Criteria® Supplemental Breast Cancer Screening Based on Breast Density: 2024 Update (Journal of the American College of Radiology)
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IBIS software incorporating the Tyrer-Cuzick model (Cancer Research Horizons)
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Surgery to Reduce the Risk of Breast Cancer (National Cancer Institute)
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BRCA1 or BRCA2 – risk management (female) (eviQ)
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Breast Density and Your Mammogram Report (American Cancer Society)
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Breast Cancer: Screening (U.S. Preventive Services Task Force)
- Dr. Lisa Mosconi